Apretude ViiV Healthcare | Cabotegravir (PrEP) | INSTI (Long-Acting PrEP) | Reimbursed | Authorised and marketed in Spain. Public financing was approved with restrictions: HIV-negative people weighing at least 35 kg who meet the criteria for oral tenofovir/emtricitabine PrEP and have an additional reason, such as hypersensitivity, kidney or bone problems, swallowing difficulty, adherence problems or chemsex. The effective date of financing is not stated in the sources. [Sources: https://www.sanidad.gob.es/areas/farmacia/precios/comisionInteministerial/informesPublicos/docs/InformePublicoApretude.pdf (published 29 April 2026) ; https://www.sanidad.gob.es/gabinete/notasPrensa.do?id=6860 (26 February 2026)] | 02/11/2026 |
Biktarvy Gilead Sciences | Bictegravir / Emtricitabine / TAF | INSTI + NRTI/NtRTI | Reimbursed | Fully financed through the national health insurance framework via specialized clinic infrastructure. [Source: Local Ministry of Health / ECDC reports] | 14/09/2026 |
Celsentri ViiV Healthcare | Maraviroc | Entry Inhibitor | Reimbursed | Fully financed through the national health insurance framework via specialized clinic infrastructure. [Source: Local Ministry of Health / ECDC reports] | 14/09/2026 |
Delstrigo Merck | Doravirine / Lamivudine / Tenofovir DF | NNRTI + NRTI/NtRTI | Reimbursed | Fully financed through the national health insurance framework via specialized clinic infrastructure. [Source: Local Ministry of Health / ECDC reports] | 14/09/2026 |
Descovy Gilead Sciences | Emtricitabine / TAF | NRTI | Reimbursed | Fully financed through the national health insurance framework via specialized clinic infrastructure. [Source: Local Ministry of Health / ECDC reports] | 14/09/2026 |
Dovato ViiV Healthcare | Dolutegravir / Lamivudine | INSTI + NRTI | Reimbursed | Fully financed through the national health insurance framework via specialized clinic infrastructure. [Source: Local Ministry of Health / ECDC reports] | 14/09/2026 |
Edurant Janssen | Rilpivirine | NNRTI | Reimbursed | Fully financed through the national health insurance framework via specialized clinic infrastructure. [Source: Local Ministry of Health / ECDC reports] | 14/09/2026 |
Generic TDF/FTC (Emtricitabine/Tenofovir DF) Multiple (Generics) | Emtricitabine / Tenofovir DF | NRTI | Reimbursed | Generic combinations are widely accessible and reimbursed under standard national health policies. [Source: Local Ministry of Health / ECDC reports] | 14/09/2026 |
Genvoya Gilead Sciences | Elvitegravir / Cobicistat / Emtricitabine / TAF | INSTI + NRTI/NtRTI + pharmacokinetic enhancer | Reimbursed | Fully financed through the national health insurance framework via specialized clinic infrastructure. [Source: Local Ministry of Health / ECDC reports] | 14/09/2026 |
Intelence Janssen | Etravirine | NNRTI | Reimbursed | Fully financed through the national health insurance framework via specialized clinic infrastructure. [Source: Local Ministry of Health / ECDC reports] | 14/09/2026 |
Isentress Merck | Raltegravir | INSTI | Reimbursed | Fully financed through the national health insurance framework via specialized clinic infrastructure. [Source: Local Ministry of Health / ECDC reports] | 14/09/2026 |
Juluca ViiV Healthcare | Dolutegravir / Rilpivirine | INSTI + NNRTI | Reimbursed | Fully financed through the national health insurance framework via specialized clinic infrastructure. [Source: Local Ministry of Health / ECDC reports] | 14/09/2026 |
Kaletra AbbVie | Lopinavir / Ritonavir | PI | Reimbursed | Fully financed through the national health insurance framework via specialized clinic infrastructure. [Source: Local Ministry of Health / ECDC reports] | 14/09/2026 |
Odefsey Gilead Sciences | Rilpivirine / Emtricitabine / TAF | NNRTI + NRTI/NtRTI | Reimbursed | Fully financed through the national health insurance framework via specialized clinic infrastructure. [Source: Local Ministry of Health / ECDC reports] | 14/09/2026 |
Pifeltro Merck | Doravirine | NNRTI | Reimbursed | Fully financed through the national health insurance framework via specialized clinic infrastructure. [Source: Local Ministry of Health / ECDC reports] | 14/09/2026 |
Prezista Janssen | Darunavir | PI | Reimbursed | Fully financed through the national health insurance framework via specialized clinic infrastructure. [Source: Local Ministry of Health / ECDC reports] | 14/09/2026 |
Rekambys Janssen | Rilpivirine | Long-Acting NNRTI | Reimbursed | Long-acting injectable rilpivirine used with cabotegravir for maintenance treatment in eligible virologically suppressed patients. The existing Spain record for the complete Vocabria / Rekambys regimen is classified as 'Available and Reimbursed', so this required rilpivirine component uses the same access and reimbursement status. EU regulatory update (as of 5 Oct 2026): on 31 January 2025 the European Commission extended the authorisation of Vocabria plus Rekambys long-acting injections to virologically suppressed adolescents aged 12 years and older weighing at least 35 kg (adults authorised since December 2020). National reimbursement for adolescents not verified. [Sources: https://www.ema.europa.eu/en/medicines/human/EPAR/rekambys; https://www.pharmiweb.com/press-release/2025-01-31/european-commission-authorises-viiv-healthcare-s-long-acting-injectable-vocabria-plus-rekambys-for-hiv-treatment-in-adolescents-1; https://i-base.info/htb/50121] | 14/09/2026 |
Symtuza Janssen | Darunavir / Cobicistat / Emtricitabine / TAF | PI + NRTI/NtRTI + pharmacokinetic enhancer | Reimbursed | Fully financed through the national health insurance framework via specialized clinic infrastructure. EU regulatory update (as of 5 Oct 2026): on 25 June 2026 the CHMP adopted a positive opinion extending the indication, with a new 675/150/200/10 mg tablet strength, to adults and paediatric patients aged 6 years and older weighing at least 25 kg (previously adolescents aged 12 years and older weighing at least 40 kg). European Commission decision not confirmed during this review; national availability and reimbursement of the new strength not verified. [Sources: Local Ministry of Health / ECDC reports; https://www.ema.europa.eu/en/medicines/human/variation/symtuza] | 14/09/2026 |
Tivicay ViiV Healthcare | Dolutegravir | INSTI | Reimbursed | Fully financed through the national health insurance framework via specialized clinic infrastructure. [Source: Local Ministry of Health / ECDC reports] | 14/09/2026 |
Triumeq ViiV Healthcare | Dolutegravir / Abacavir / Lamivudine | INSTI + NRTI | Reimbursed | Fully financed through the national health insurance framework via specialized clinic infrastructure. [Source: Local Ministry of Health / ECDC reports] | 14/09/2026 |
Truvada Gilead Sciences | Emtricitabine / Tenofovir DF | NRTI | Reimbursed | Fully financed through the national health insurance framework via specialized clinic infrastructure. [Source: Local Ministry of Health / ECDC reports] | 14/09/2026 |
Vocabria ViiV Healthcare | Cabotegravir | INSTI | Reimbursed | Fully financed through the national health insurance framework via specialized clinic infrastructure. EU regulatory update (as of 5 Oct 2026): on 31 January 2025 the European Commission extended the authorisation of Vocabria plus Rekambys long-acting injections to virologically suppressed adolescents aged 12 years and older weighing at least 35 kg (adults authorised since December 2020). National reimbursement for adolescents not verified. [Sources: Local Ministry of Health / ECDC reports; https://www.pharmiweb.com/press-release/2025-01-31/european-commission-authorises-viiv-healthcare-s-long-acting-injectable-vocabria-plus-rekambys-for-hiv-treatment-in-adolescents-1; https://i-base.info/htb/50121] | 14/09/2026 |
Vocabria / Rekambys ViiV Healthcare / Janssen | Cabotegravir / Rilpivirine | Long-Acting ART | Reimbursed | EMA approved. Fully or partially reimbursed under the national health system for virologically suppressed patients. EU regulatory update (as of 5 Oct 2026): on 31 January 2025 the European Commission extended the authorisation of Vocabria plus Rekambys long-acting injections to virologically suppressed adolescents aged 12 years and older weighing at least 35 kg (adults authorised since December 2020). National reimbursement for adolescents not verified. [Sources: Local Ministry of Health / ECDC reports; https://www.pharmiweb.com/press-release/2025-01-31/european-commission-authorises-viiv-healthcare-s-long-acting-injectable-vocabria-plus-rekambys-for-hiv-treatment-in-adolescents-1; https://i-base.info/htb/50121] | 14/09/2026 |
Rukobia ViiV Healthcare | Fostemsavir | Attachment Inhibitor | Available, not reimbursed | Approved by EMA, but may require special funding requests or is restricted to highly treatment-experienced patients. [Source: Local Ministry of Health / ECDC reports] | 14/09/2026 |
Sunlenca Gilead Sciences | Lenacapavir | Capsid Inhibitor | Available, not reimbursed | Approved by EMA, but may require special funding requests or is restricted to highly treatment-experienced patients. [Source: Local Ministry of Health / ECDC reports] | 14/09/2026 |
Emtricitabine / Rilpivirine / Tenofovir Alafenamide Viatris Viatris Limited | Emtricitabine / Rilpivirine / Tenofovir alafenamide | NNRTI + NRTI/NtRTI | Not available | Authorised in Spain in February 2026 but not yet marketed according to the AEMPS medicines register (CIMA), checked 2 November 2026. [Source: https://cima.aemps.es/cima/rest/medicamentos?nombre=tenofovir%20alafenamida%20viatris] | 02/11/2026 |
Emtricitabine / Tenofovir alafenamide Viatris Viatris Limited | Emtricitabine / Tenofovir alafenamide | NRTI/NtRTI | Not available | Authorised in Spain in February 2026 but not yet marketed according to the AEMPS medicines register (CIMA), checked 2 November 2026. [Source: https://cima.aemps.es/cima/rest/medicamentos?nombre=tenofovir%20alafenamida%20viatris] | 02/11/2026 |
Evotaz Bristol Myers Squibb | Atazanavir / Cobicistat | PI + pharmacokinetic enhancer | Not available | Authorised in Spain but not marketed according to the AEMPS medicines register (CIMA), checked 2 November 2026. [Source: https://cima.aemps.es/cima/rest/medicamentos?nombre=evotaz] | 02/11/2026 |
Generic TLD (Tenofovir/Lamivudine/Dolutegravir) Multiple (Generics) | Tenofovir DF / Lamivudine / Dolutegravir | INSTI + NRTI/NtRTI | Not available | Generic combinations are typically not procured as branded single-tablet regimens are widely available. [Source: Local Ministry of Health / ECDC reports] | 14/09/2026 |
Generic TLE (Tenofovir/Lamivudine/Efavirenz) Multiple (Generics) | Tenofovir DF / Lamivudine / Efavirenz | NNRTI + NRTI/NtRTI | Not available | Generic combinations are typically not procured as branded single-tablet regimens are widely available. [Source: Local Ministry of Health / ECDC reports] | 14/09/2026 |
Reyataz Bristol Myers Squibb | Atazanavir | PI | Not available | Authorised in Spain but not marketed according to the AEMPS medicines register (CIMA), checked 2 November 2026. [Source: https://cima.aemps.es/cima/rest/medicamentos?nombre=reyataz] | 02/11/2026 |
Emtriva Gilead Sciences | Emtricitabine | NRTI | Under review | Emtricitabine is a nucleoside reverse transcriptase inhibitor used with other antiretroviral medicines for HIV-1 treatment. EMA confirms an EU/EEA-wide marketing authorisation. Product-specific national marketing, supply and reimbursement were not independently confirmed during this review; reimbursement status remains under review. [Source: https://www.ema.europa.eu/en/medicines/human/EPAR/emtriva] | 14/09/2026 |
Epivir ViiV Healthcare | Lamivudine | NRTI | Under review | Lamivudine is a nucleoside reverse transcriptase inhibitor used as part of combination antiretroviral therapy. EMA confirms an EU/EEA-wide marketing authorisation. Product-specific national marketing, supply and reimbursement were not independently confirmed during this review; reimbursement status remains under review. [Source: https://www.ema.europa.eu/en/medicines/human/EPAR/epivir] | 14/09/2026 |
Eviplera Gilead Sciences | Rilpivirine / Emtricitabine / Tenofovir DF | NNRTI + NRTI/NtRTI | Under review | A once-daily fixed-dose HIV-1 regimen containing rilpivirine, emtricitabine and tenofovir disoproxil; resistance history and viral-load restrictions apply. EMA confirms an EU/EEA-wide marketing authorisation. Product-specific national marketing, supply and reimbursement were not independently confirmed during this review; reimbursement status remains under review. [Source: https://www.ema.europa.eu/en/medicines/human/EPAR/eviplera] | 14/09/2026 |
Kivexa ViiV Healthcare | Abacavir / Lamivudine | NRTI | Under review | A fixed-dose NRTI backbone containing abacavir and lamivudine; HLA-B*5701 screening is required before abacavir treatment. EMA confirms an EU/EEA-wide marketing authorisation. Product-specific national marketing, supply and reimbursement were not independently confirmed during this review; reimbursement status remains under review. [Source: https://www.ema.europa.eu/en/medicines/human/EPAR/kivexa] | 14/09/2026 |
Norvir AbbVie | Ritonavir | PI + pharmacokinetic enhancer | Under review | Ritonavir is a protease inhibitor used mainly at low dose as a pharmacokinetic enhancer for other protease inhibitors. EMA confirms an EU/EEA-wide marketing authorisation. Product-specific national marketing, supply and reimbursement were not independently confirmed during this review; reimbursement status remains under review. EU regulatory update (as of 5 Oct 2026): on 18 September 2025 the CHMP adopted a positive opinion recommending changes to the existing indication and contraindications of Norvir, including guidance that when ritonavir is used as a pharmacokinetic enhancer the SmPC of the co-administered protease inhibitor should be consulted for contraindications. European Commission decision not confirmed during this review. [Sources: https://www.ema.europa.eu/en/medicines/human/EPAR/norvir; https://www.ema.europa.eu/en/medicines/human/variation/norvir] | 14/09/2026 |
Retrovir ViiV Healthcare | Zidovudine | NRTI | Under review | Zidovudine is a nucleoside reverse transcriptase inhibitor used with other antiretroviral medicines; it is now generally a specialised or alternative treatment option. EMA confirms an EU/EEA-wide marketing authorisation. Product-specific national marketing, supply and reimbursement were not independently confirmed during this review; reimbursement status remains under review. [Source: https://www.ema.europa.eu/en/medicines/human/EPAR/retrovir] | 14/09/2026 |
Rezolsta Janssen | Darunavir / Cobicistat | PI + pharmacokinetic enhancer | Under review | A fixed-dose combination of darunavir and cobicistat used with other antiretrovirals. EMA's CHMP issued a positive opinion on 25 June 2026 for a dispersible formulation and paediatric use from age 3 years and 15 kg. EMA confirms an EU/EEA-wide marketing authorisation. Product-specific national marketing, supply and reimbursement were not independently confirmed during this review; reimbursement status remains under review. [Source: https://www.ema.europa.eu/en/medicines/human/EPAR/rezolsta] | 14/09/2026 |
Stribild Gilead Sciences | Elvitegravir / Cobicistat / Emtricitabine / Tenofovir DF | INSTI + NRTI/NtRTI + pharmacokinetic enhancer | Under review | A once-daily fixed-dose HIV-1 regimen containing an integrase inhibitor, pharmacokinetic enhancer and two reverse transcriptase inhibitors. EMA confirms an EU/EEA-wide marketing authorisation. Product-specific national marketing, supply and reimbursement were not independently confirmed during this review; reimbursement status remains under review. [Source: https://www.ema.europa.eu/en/medicines/human/EPAR/stribild] | 14/09/2026 |
Viread Gilead Sciences | Tenofovir DF | NtRTI | Under review | Tenofovir disoproxil is a nucleotide reverse transcriptase inhibitor used with other antiretrovirals for HIV-1 treatment; renal and bone monitoring may be relevant. EMA confirms an EU/EEA-wide marketing authorisation. Product-specific national marketing, supply and reimbursement were not independently confirmed during this review; reimbursement status remains under review. [Source: https://www.ema.europa.eu/en/medicines/human/EPAR/viread] | 14/09/2026 |
Yeytuo Gilead Sciences | Lenacapavir (PrEP) | Capsid Inhibitor (Long-Acting PrEP) | Under review | Twice-yearly injectable lenacapavir for pre-exposure prophylaxis; a separate marketing authorisation from Sunlenca, which covers treatment. The European Commission granted an EU/EEA-wide marketing authorisation on 26 August 2025 following accelerated EMA assessment. Country-level marketing, supply and reimbursement have not yet been verified. [Source: https://www.ema.europa.eu/en/medicines/human/EPAR/yeytuo] | 14/09/2026 |
Ziagen ViiV Healthcare | Abacavir | NRTI | Under review | Abacavir is a nucleoside reverse transcriptase inhibitor used in combination therapy; HLA-B*5701 screening is required before treatment. EMA confirms an EU/EEA-wide marketing authorisation. Product-specific national marketing, supply and reimbursement were not independently confirmed during this review; reimbursement status remains under review. [Source: https://www.ema.europa.eu/en/medicines/human/EPAR/ziagen] | 14/09/2026 |